Special Topic: Medication-Assisted Treatment
The Induction Problem:
XR Naltrexone (Vivitrol®) For The Treatment of Opioid Use Disorder: Part I
Ned Presnall, LCSW
Executive Director, Clayton Behavioral
St. Louis, MO
For several years after its 2011 FDA approval, there existed only one randomized controlled trial of XR naltrexone for opioid use disorder: a placebo-controlled trial conducted in Russia. In late 2017 and early 2018, results from two randomized controlled trials were published comparing the effectiveness of XR naltrexone with buprenorphine.This article aims to answer some very practical but difficult questions about XR naltrexone:
- How should the recent head-to-head clinical trials and original Russian study inform our policy and practice as we address the epidemic of opioid-related deaths?
- Is XR naltrexone equally or more effective than buprenorphine and methadone for retaining patients in treatment and reducing illicit opioid use?
Part I of this article will cover the original Russian study, the controversy surrounding it, and key design choices that run through all three studies. Next month, Part II will cover the head-to-head trials, and Part III will provide a summary perspective on all three medications and discuss policy implications of the XR naltrexone clinical trials.
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Addiction Science Made Easy
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New from SAMHSA
Strategy to Combat Opioid Abuse, Misuse, and Overdose: A Framework Based on the Five Point Strategy
Click to read the Comprehensive Strategy PDF.
The State Targeted Response (STR) Technical Assistance (TA) Consortium was created to provide local expertise in communities to help address the opioid public health crisis. To find out more or submit a technical assistance request, visit the STR-TA website!
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New from the ATTC Network!
ATTC Educational Packages for Opioid Use Disorders
The ATTC Network Coordinating Office has designed three new digital guides that feature resources for addressing the opioid crisis.
Visit the ATTC project webpage,
Taking Action to Address Opioid Misuse, to view the guides:
Peer Support Workers
Counselors and Psychologists
Social Workers
Want to find out more about the Educational Packages?
Join our Twitter Chat
Tuesday, October 30
3:00 ET, 2:00 CT, 1:00 MT, 12:00PT
@ATTCnetwork
#knowmoreopioids
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